Īlthough there is no one single accepted age cut-off to define ‘elderly’, data suggests that recipients greater than age 60, or 65, or 70 are particularly vulnerable to poor outcomes in the presence of other medical comorbidities. As a result of increasing life expectancy across the world, the demand for liver transplantation is expected to increase in the elderly population. Based on the latest United States Vitals report, the life expectancy of people at age 60 is about 23.3 years and the life expectancy at 70 years of age is 15.7 years. Refinements in surgical techniques and improved post-operative care have made this possible. Prevalence and incidence of ESLD have increased in the elderly, resulting in increased rates of liver transplantation among the elderly population across the globe. Liver transplantation increases the probability of survival for patients with end-stage liver disease (ESLD). Patients ≥70 years undergoing liver transplantation seem to demonstrate significantly lower 1-year and 5-year survival rates as compared to patients <70 years, albeit limited by heterogeneity. The pooled rate of perioperative mortality in patients ≥70 years was 16.6% (7.6–32.5 I 2=99%) and in patients <70 years was 0.8% (0–33.1 I 2=88%). The pooled rate of perioperative complications in patients ≥70 years was 40.7% (26.2–57 I 2=93%). Descriptive p-values of comparison were statistically significant at 1-year and 5-years ( p = 0.02 and <0.001). Ten studies were included that analyzed 162,725 patients. Meta-analysis was conducted using the random-effects model and heterogeneity was assessed using the I 2 statistics. Multiple databases were searched through March 2022 for studies that reported on the outcomes of liver-transplantation in patients ≥70 years. Given the scarcity in liver allograft resources, a meta-analysis on the outcomes of liver transplantation in patients ≥70 years is warranted. The rate of liver transplantation is increasing among the elderly population however, data is limited on the post-liver transplantation outcomes in patients ≥70 years. Our journal seeks to publish articles on basic clinical care and translational research focused on preventing rather than treating the complications of end-stage liver disease. Topics covered by AoH include alcoholic liver disease, autoimmune hepatitis, biliary diseases, drug-induced liver injury, genetic liver diseases, NAFLD/NASH and viral hepatitis (HAV, HBV, HCV, HDV, HEV). AoH publishes editorials, opinions, concise reviews, original articles, brief reports, letters to the editor, news from affiliated associations, clinical practice guidelines and summaries of congresses in the field of Hepatology. It is the official journal of the Mexican Association of Hepatology ( AMH), the Latin American Association for the Study of the Liver ( ALEH), the Canadian Association for the Study of the Liver ( CASL) and the Czech Society of Hepatology ( CSH). Annals of Hepatology (AoH) is an international, open access journal published bi-monthly with funds from the Fundación Clínica Médica Sur.
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